This talk explores the life of Crispina Peres, the most powerful trader in Cacheu, a key West African slave port, who was arrested by the Inquisition in 1665. Accused of using treatments from Senegambian healers, she became a target in a broader struggle over faith and power. Professor Green transports us to seventeenth-century Cacheu, revealing its daily life, culture, and the brutal realities of the expanding slave trade. Through Peres’s case, we uncover a globally connected world where women defied imperial patriarchy, challenging the narratives of European dominance. This talk has been organised by BCDSS fellow Ana Lucia Araujo.